Vericiguat (formerly BAY-1021189; BAY10-21189; Verquvo) is an orally bioavailable and potent soluble guanylate cyclase (sGC) stimulator that has been approved in 2021 by FDA to reduce the risk of cardiovascular death and heart failure (HF).

Linaclotide (trade name Linzess in the US and Mexico, and as Constella elsewhere) is a novel, potent, selective and orally administered, peptide agonist of guanylate cyclase C developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.

BAY-41-8543 is a novel and potent NO-independent guanylyl cyclase stimulator.

Methylthioninium chloride hydrate (C.I. Basic Blue 9 trihydrate) is an inhibitor of guanylyl cyclase (sGC) as well as monoamine oxidase A (MAO-A) and NO synthase (NOS).

Plecanatide (Trade name Trulance; formerly SP304; SP-304), a 16 amino acid peptide and a synthetic analog of uroguanylin, is a drug approved by FDA for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation.