BAY-41-8543
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $850 | Check With Us |
| 100mg | $1275 | Check With Us |
| 200mg | $1915 | Check With Us |
: Cat #: V5898 CAS #: 256498-66-5 Purity ≥ 99%
Description: BAY-41-8543 is a novel and potent NO-independent guanylyl cyclase stimulator.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 420.44 |
|---|---|
| Molecular Formula | C21H21FN8O |
| CAS No. | 256498-66-5 |
| Protocol | In Vivo | BAY 41-8543 (10-100 μg/kg; IV) produces small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output |
|---|---|---|
| Animal model | Adult male Sprague-Dawley rats weighing 325-450 g | |
| Dosages | 10, 30, and 100 μg/kg |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3785 mL | 11.8923 mL | 23.7846 mL | 47.5692 mL |
| 5mM | 0.4757 mL | 2.3785 mL | 4.7569 mL | 9.5138 mL |
| 10mM | 0.2378 mL | 1.1892 mL | 2.3785 mL | 4.7569 mL |
| 20mM | 0.1189 mL | 0.5946 mL | 1.1892 mL | 2.3785 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.