AZD0364 is a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC.

VX-11e is a novel, potent, selective, and orally bioavailable ERK2 (extracellular signal-related kinase 2) inhibitor with potential anticancer activity.

Ulixertinib (formerly also known as BVD-523 and VRT752271) is a novel, potent, orally bioactive, highly selective, ATP-competitive and reversible ERK1/ERK2 inhibitor with potential antineoplastic activity.

Hypaphorine is a novel and potent indole alkaloid.

Astragaloside IV (AS-IV), the major active component found in Astragalus membranaceus, has broad application prospects, especially in cardiovascular diseases, digestive diseases, cancer and other modern high incidence, high-risk diseases, and could be developed as a medicine.

AX15836 is a novel, highly potent and selective ERK5 inhibitor (IC50 = 8 nM).

Trametinib DMSO solvate is the solvated form of trametinib (trametinib: dimethyl sulfoxide=1:1) and a potent MEK inhibitor that specifically inhibits MEK1/2 with an IC50 value of about 2 nM.

XMD8-85 is a novel and potent ERK5 and LRRK2 inhibitor.

Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, which is used for the treatment of gallstones and liver cirrhosis.

Piperlongumine (Piplartine) is a naturally occuring and biologically active alkaloid isolated from peppers especcially long peppers such as Piper longum Linn, which possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities.