AX15836
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1575 | To Be Confirmed |
| 200mg | $2360 | To Be Confirmed |
| 500mg | $3980 | To Be Confirmed |
: Cat #: V11971 CAS #: 2035509-96-5 Purity ≥ 98%
Description: AX15836 is a novel, highly potent and selective ERK5 inhibitor (IC50 = 8 nM).
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| Molecular Weight (MW) | 648.78 |
|---|---|
| Molecular Formula | C32H40N8O5S |
| CAS No. | 2035509-96-5 |
| SMILES Code | O=C1C2=CC=CC=C2N(S(=O)(C)=O)C3=NC(NC4=CC=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4OCC)=NC=C3N1C |
| Synonyms | AX15836; AX 15836; AX-15836 |
| Protocol | In Vitro | AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. AX15836 shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5414 mL | 7.7068 mL | 15.4135 mL | 30.8271 mL |
| 5mM | 0.3083 mL | 1.5414 mL | 3.0827 mL | 6.1654 mL |
| 10mM | 0.1541 mL | 0.7707 mL | 1.5414 mL | 3.0827 mL |
| 20mM | 0.0771 mL | 0.3853 mL | 0.7707 mL | 1.5414 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.