Btk inhibitor 1 R-enantiomer hydrochloride (IBT6A hydrochloride), the R-isomer and hydrochloride salt form of Btk inhibitor 1, is a novel and potent Bruton’s tyrosine kinase (BTK) inhibitor with potential antitumor activity.

(±)-Zanubrutinib is a racemic mixture of Zanubrutinib (formerly known as BGB-3111) which is a novel, highly selective, second generation BTK inhibitor, currently under clinical investigation in hematological cancers.

Spebrutinib (formerly known as AVL-292 and CC-292) is a novel, potent, covalent/irreversible, orally bioactive, and highly selective Btk kinase inhibitor with an IC50 of 0.5 nM.

Orelabrutinib (ICP-022; ICP022; ICP 022) is an oral bioavailable, new generation and irreversible/covalent Bruton’s tyrosine kinase (BTK) inhibitor with the potential to be used for the treatment of cancer such as B-cell lymphomas and autoimmune indications.

BMS-986142, a carbazole and tetrahydrocarbazole based compound, is a novel, potent and highly selective reversible Bruton’s tyrosine kinase (BTK) inhibitor with an IC50 of 0.5 nM.

(R)-Zanubrutinib is the R-enantiomer of Zanubrutinib (formerly known as BGB-3111) which is a novel, highly selective, second generation BTK inhibitor, currently under clinical investigation in hematological cancers.

Tirabrutinib (formerly ONO-4059; GS4059; ONO-WG-307; Steboronine) is a novel, potent, highly selective, covalent/irreversible and orally bioavailable BTK (Bruton agammaglobulinemia tyrosine kinase) inhibitor with anticancer activity.

Branebrutinib (formerly BMS-986195) is a highly selective and rapidly acting covalent/irreversible inhibitor of Bruton’s Tyrosine Kinase (BTK) with IC50 of<1 nM and robust efficacy at low doses in preclinical models of RA (Rheumatoid Arthritis) and Lupus Nephritishighly.

BTK IN-1 (SNS-062 analog or Vecabrutinib analog) is a novel and potent BTK (Bruton’s tyrosine kinase) inhibitor with an IC50 of<100 nM.

PCI 29732 is a novel, potent, selective and irreversible Btk (Bruton’s tyrosine kinase) inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.