BTK IN-1 | CAS 1270014-40-8

BTK IN-1

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1450	Check With Us
500mg	$2080	Check With Us
1g	$3120	Check With Us

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Cat #: V4766 CAS #: 1270014-40-8 Purity ≥ 98%

Description: BTK IN-1 (SNS-062 analog or Vecabrutinib analog) is a novel and potent BTK (Bruton's tyrosine kinase) inhibitor with an IC50 of<100 nM.

References: Minna Bui, et al. Heteroaryl btk inhibitors. WO2011029043A1

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	384.86
Molecular Formula	C19H21ClN6O
CAS No.	1270014-40-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C(CNC1=CC(Cl)=CC=C1)NC(CCC2)CN2C3=NC=NC4=C3C=CN4
Synonyms	SNS062-analog; SNS 062-analog; SNS 062-analo

Protocol	In Vitro	BTK IN-1 (Compound 21) is a potent BTK inhibitor, with an IC50 of <100 nM.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5983 mL	12.9917 mL	25.9835 mL	51.9669 mL
5mM	0.5197 mL	2.5983 mL	5.1967 mL	10.3934 mL
10mM	0.2598 mL	1.2992 mL	2.5983 mL	5.1967 mL
20mM	0.1299 mL	0.6496 mL	1.2992 mL	2.5983 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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