SR-59230A oxalate (SR59230A) is a novel, potent, blood-brain barrier penetrating, and selective β3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for β3, β1 and β2 receptors respectively).
Prazosin HCl (Furazosin, cp12299-1; cp-12299-1; Minipress, Peripress), the hydrochloride salt of prazosin, is a potent and competitive alpha-1 adrenoceptor antagonist with antihypertensive effects.
Yohimbine HCl (Antagonil; Corynine; Quebrachin; Quebrachine; Yohimex; Yocon; APHRODINE; Aphrodyne; Aphrosol; Johimbin), the hydrochloride salt of Yohimbine, is a potent alpha 2-adrenoreceptor antagonist used as a mydriatic for the treatment of impotence.
Atipamezole (Antisedan, MPV-1248) is a synthetic α2 adrenergic receptor antagonist with a Ki of 1.6 nM.
Hydroxybupropion is a major metabolite of Bupropion (trade names Wellbutrin and Zyban) which is a marketed antidepressant and a smoking cessation drug.
Vilanterol trifenatate (formerly GW-642444; Anoro Ellipta; Breo Ellipta), the trifenatate salt of vilanterol, is an ultra-long-acting β2-adrenoceptor/ beta-2 (β2-AR) agonist approved in May 2013 for use in combination with fluticasone furoate (Breo Ellipta) and also in combination with Umeclidinium bromide (Anoro Ellipta) for the treatment of chronic obstructive pulmonary disease (COPD).
Talipexole dihydrochloride (also known as B-HT920, Domnin, B-HT-920 dihydrochloride) is a novel and potent dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays anti-parkinsonian activity.
Mirabegron (formerly YM-178; YM178; Myrbetriq; Betanis; Betmiga) is a potent and selective β3-adrenoceptor agonist with similar effects to antimuscarinic medications.
Betaxolol (Betoptima; Kerlone; Betoptic; Kerlon; SL-75212 HCl; ALO-140102) is a β1 adrenergic receptor antagonist/blocker with antihypertensive effects.
Scopine (6,7-Epoxytropine), a metabolite of scopolamine and anisodine (an α1-adrenergic receptor agonist), is a naturally occurring tropane alkaloid extracted from various plants such as Scopolia carniolica, Mandragora root, Senecio mikanoides (Delairea odorata), and Scopolia lurida.