Mirtazapine (formerly Org3770, Org 3770; trade names Remeron, Avanza, Axit, Mirtazon, Zispin), an approved atypical antidepressant drug, is an adrenergic and serotonin receptor antagonist used for treating depression.

Intepirdine HCl (GSK-742457; SB742457; RVT-101), the hydrochloride salt of Intepirdine, is a novel, potent and highly selective 5-HT6 receptor antagonist with pKi of 9.63; it exhibits >100-fold selectivity over other receptors.

NLX-101, formerly known as F-15599, is a G-protein biased compound that activates serotonin 5-HT1A receptors with exceptional selectivity, having over 1000-fold higher affinity for this target over other receptors.

AVN-492 is a highly specific, selective and orally bioavailable antagonist of the 5-HT6R with Ki of 91 pM.

Naratriptan HCl (GR-85548A; GR85548A; Amerge; Naramig), the hydrochloride salt of naratriptan, is a triptan class of selective 5-HT₁ receptor subtype agonist used for the treatment of migraine headaches.

Aripiprazole monohydrate (formerly also known as OPC-14597; OPC31; Abilitat), the monohydrated form of Aripiprazole, is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.

8-OH-DPAT (also known as 8-Hydroxy-DPAT) is a classic, potent and selective agonist of 5-HT1A with the potential to be used for sleep disorders.

Ziprasidone HCl hydrate (CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist approved for treatment of schizophrenia, has antipsychotic activity.

Pardoprunox (formerly known as SLV-308, DU-126891 or SME-308) is novel & potent dopamine D2/5-HT1A receptor agonist that has the potential for the treatment of Parkinson’s disease.

Vortioxetine HBr (formerly AA21004, Lu-AA21004, AA21004; Lu AA21004), the hydrobromide salt of Vortioxetine which is a marketed and atypical antidepressant, is an orally bioactive and multimodal serotonergic agent with potential anti-depressive activity.