8-OH-DPAT
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $950 | Check With Us |
| 1g | $1425 | Check With Us |
: Cat #: V2790 CAS #: 78950-78-4 Purity ≥ 98%
Description: 8-OH-DPAT (also known as 8-Hydroxy-DPAT) is a classic, potent and selective agonist of 5-HT1A with the potential to be used for sleep disorders.
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| Molecular Weight (MW) | 247.38 |
|---|---|
| Molecular Formula | C16H25NO |
| CAS No. | 78950-78-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 49 mg/mL (198.07 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 49 mg/mL (198.07 mM) | |
| Synonyms | 8-Hydroxy-DPAT; 8-OH-DPAT; 8-Hydroxy-DPAT; 8OH-DPAT |
| Protocol | In Vivo | 8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.0424 mL | 20.2118 mL | 40.4236 mL | 80.8473 mL |
| 5mM | 0.8085 mL | 4.0424 mL | 8.0847 mL | 16.1695 mL |
| 10mM | 0.4042 mL | 2.0212 mL | 4.0424 mL | 8.0847 mL |
| 20mM | 0.2021 mL | 1.0106 mL | 2.0212 mL | 4.0424 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.