Probenecid (Benemid)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $150 | Check With Us |
| 100g | $800 | Check With Us |
| 200mg | $1200 | Check With Us |
: Cat #: V1686 CAS #: 57-66-9 Purity ≥ 98%
Description: Probenecid (Benemid; Probecid; Benecid; Benuryl; Probenecid Martec; Probalan) is an OAT (organic anion transport) inhibitor which has been used as a medication to increase uric acid excretion in the urine.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 285.36 |
|---|---|
| Molecular Formula | C13H19NO4S |
| CAS No. | 57-66-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 57 mg/mL (199.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 22 mg/mL (77.1 mM) | |
| Synonyms | Benemid; Benecid; Benuryl; Probecid; Probenecid Martec; Probenecid |
| Protocol | In Vivo | Probenecid results in increased contractility in WT mice, as measured by ejection fraction (EF), relative to EF in control mice given saline. At all doses of 75 mg/kg or more, increased contractility was noted within 5 minutes of bolus (peak variation of 75.100± 200.5, 26.3± 35.8, 40.2±80.7, respectively, at all doses of 32 mg/kg or more). Changes in contractility measured at 2-minute intervals (52 min total) indicate a dose-dependent increase in contractility, estimated EC50 is 49.33 mg/kg. In subjects assessed over a longer period of time (n=5, dose 200 mg/kg IV), EF remained elevated for at least 1 hour (mean increase in EF from baseline 8.9±2.57) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5043 mL | 17.5217 mL | 35.0435 mL | 70.0869 mL |
| 5mM | 0.7009 mL | 3.5043 mL | 7.0087 mL | 14.0174 mL |
| 10mM | 0.3504 mL | 1.7522 mL | 3.5043 mL | 7.0087 mL |
| 20mM | 0.1752 mL | 0.8761 mL | 1.7522 mL | 3.5043 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.