Pritelivir (BAY 57-1293)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1225 | Check With Us |
: Cat #: V1747 CAS #: 348086-71-5 Purity ≥ 98%
Description: Pritelivir (formerly known as AIC-316; BAY-57-1293; AIC316; BAY571293) is a novel and potent helicase primase inhibitor that displays antiviral effects against herpes simplex virus (HSV) with an IC50 of 20 nM for both HSV-1 and HSV-2.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 402.49 |
|---|---|
| Molecular Formula | C18H18N4O3S2 |
| CAS No. | 348086-71-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 80 mg/mL (198.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C(N(C)C1=NC(C)=C(S(=O)(N)=O)S1)CC2=CC=C(C3=NC=CC=C3)C=C2 |
| Synonyms | AIC 316; BAY57-1293; BAY 57-1293; AIC-316; BAY-57-1293; AIC316; BAY571293; BAY 571293; BAY-571293; Pritelivir. |
| Protocol | In Vivo | Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis |
|---|---|---|
| Animal model | Female BALB/c mice | |
| Dosages | 0.03 to 45 mg/kg | |
| Administration | Administered orally, twice daily at approximately 12 h intervals, for 7 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4845 mL | 12.4227 mL | 24.8453 mL | 49.6907 mL |
| 5mM | 0.4969 mL | 2.4845 mL | 4.9691 mL | 9.9381 mL |
| 10mM | 0.2485 mL | 1.2423 mL | 2.4845 mL | 4.9691 mL |
| 20mM | 0.1242 mL | 0.6211 mL | 1.2423 mL | 2.4845 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.