Pristimerin

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$650	To Be Confirmed
200mg	$975	To Be Confirmed
500mg	$1645	To Be Confirmed

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Cat #: V13134 CAS #: 1258-84-0 Purity ≥ 99%

Description: Pristimerin (Celastrol-methylether; UNII-28ZK7PR57S) is a naturally occurring triterpenoid, acting as a reversible monoacylglycerol lipase (MGL) inhibitor (IC50 = 93 nM) with antitumor activity.

References: King AR, et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol. 2009 Oct 30;16(10):1045-52.

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Molecular Weight (MW)	464.64
Molecular Formula	C30H40O4
CAS No.	1258-84-0
SMILES Code	C[C@@]12CC[C@](C([C@](C)3CC4)=CC=C(C(C)=C5O)C3=CC5=O)(C)[C@@]4(C)[C@@H]1C[C@](C(OC)=O)(C)CC2
Synonyms	Pristimerin; Celastrol-methylether; UNII-28ZK7PR57S;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1522 mL	10.7610 mL	21.5220 mL	43.0441 mL
5mM	0.4304 mL	2.1522 mL	4.3044 mL	8.6088 mL
10mM	0.2152 mL	1.0761 mL	2.1522 mL	4.3044 mL
20mM	0.1076 mL	0.5381 mL	1.0761 mL	2.1522 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.