XEN445 (XEN-445) is a novel, potent and selective endothelial lipase (EL) inhibitor (IC50 = 0.237 μM) with favorable ADME and PK properties, as well as in vivo efficacy in raising plasma HDLc concentrations in mice.

Cetilistat (previously known as ATL-962) is a novel inhibitor of pancreatic and gastrointestinal lipases.

Pristimerin (Celastrol-methylether; UNII-28ZK7PR57S) is a naturally occurring triterpenoid, acting as a reversible monoacylglycerol lipase (MGL) inhibitor (IC50 = 93 nM) with antitumor activity.