Home > Signaling Pathways>Immunology/Inflammation>TLR>Polyinosinic-polycytidylic acid sodium
Polyinosinic-polycytidylic acid sodium

This product is for research use only, not for human use. We do not sell to patients.

Polyinosinic-polycytidylic acid sodium
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1050To Be Confirmed
200mg$1575To Be Confirmed
500mg$2655To Be Confirmed
email: [email protected]        [email protected]

Cat #: V37712 CAS #: 42424-50-0 Purity ≥ 99%

Description: Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is an analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors with the potential to be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment.

References: Besch R, et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest. 2009 Aug;119(8):2399-411.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Formula(C10H13N4O8P)x.(C9H14N3O8P)x.xNa
CAS No.42424-50-0
Synonymsolyinosinic-polycytidylic acid sodium; Poly(I:C) sodium
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.