Pim1/AKK1-IN-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1500 | Check With Us |
| 500mg | $2200 | Check With Us |
| 1g | $3300 | Check With Us |
: Cat #: V25157 CAS #: 1093222-27-5 Purity ≥ 99%
Description: Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor, targeting Pim1, AKK1, MST2, LKB1, MPSK1, and TNIK.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 339.35 |
|---|---|
| Molecular Formula | C20H13N5O |
| CAS No. | 1093222-27-5 |
| SMILES Code | O=C(C1=CC=CN=C1)NC2=CNC3=NC=C(C4=CC=C(C#N)C=C4)C=C32 |
| Synonyms | LKB1/AAK1 dual inhibitor; MDK-2275; MDK 2275; MDK2275; |
| Protocol | In Vitro | Pim1/AKK1-IN-1 is multi-kinase inhibitor, and has Kd of 380 nM against LKB1 and 53 nM against AAK1. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9468 mL | 14.7341 mL | 29.4681 mL | 58.9362 mL |
| 5mM | 0.5894 mL | 2.9468 mL | 5.8936 mL | 11.7872 mL |
| 10mM | 0.2947 mL | 1.4734 mL | 2.9468 mL | 5.8936 mL |
| 20mM | 0.1473 mL | 0.7367 mL | 1.4734 mL | 2.9468 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.