Pilsicainide HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | To Be Confirmed |
| 250mg | $850 | To Be Confirmed |
| 500mg | $1275 | To Be Confirmed |
: Cat #: V22274 CAS #: 88069-49-2 Purity ≥ 99%
Description: Pilsicainide HCl (SUN-1165; SUN1165; SUN 1165), the hydrochloride salt of Pilsicainide, is an antiarrhythmic drug marketed in Japan the treatment of cardiac arrhythmias.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 308.85 |
|---|---|
| Molecular Formula | C17H25ClN2O |
| CAS No. | 88069-49-2 |
| Synonyms | SUN-1165; SUN 1165 |
| Protocol | In Vitro | Pilsicainide hydrochloride (SUN-1165) (10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 ± 22.9 μg/mL in levo-thyroxine (T4)-treated rat atrial cells |
|---|---|---|
| In Vivo | Pilsicainide hydrochloride (SUN-1165) (2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current | |
| Animal model | Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment | |
| Dosages | 2 mg/kg | |
| Administration | Bolus injection into right external carotid vein within 2 minutes, once |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2378 mL | 16.1891 mL | 32.3782 mL | 64.7564 mL |
| 5mM | 0.6476 mL | 3.2378 mL | 6.4756 mL | 12.9513 mL |
| 10mM | 0.3238 mL | 1.6189 mL | 3.2378 mL | 6.4756 mL |
| 20mM | 0.1619 mL | 0.8095 mL | 1.6189 mL | 3.2378 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.