Phentolamine Mesylate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$180	In Stock
10g	$288	In Stock
20g	$430	In Stock

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Cat #: V1140 CAS #: 65-28-1 Purity ≥ 98%

Description: Phentolamine Mesylate (OraVerse, Regitine mesylate, Regitine, Regityn, Rogitine, Z-Max), the mesylate/mesilate/methanesulfonate salt of Phentolamine, is a reversible and nonselective alpha-adrenergic receptor antagonist with antihypertensive effects.

References: Pan L, et, al. Phentolamine inhibits angiogenesis in vitro: Suppression of proliferation migration and differentiation of human endothelial cells. Clin Hemorheol Microcirc. 2017;65(1):31-41.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	377.46
Molecular Formula	C17H19N3O.CH4O3S
CAS No.	65-28-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 76 mg/mL (201.3 mM)r
	Water: 76 mg/mL (201.3 mM)r
	Ethanol: 76 mg/mL (201.3 mM)
Synonyms	Phentolamine mesilate, Phentolamine methanesulfonate, OraVerse, Regitine mesylate, Regitine, Regityn, Rogitine, Z-Max, Phentolamine Mesylate,

Protocol	In Vitro	Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively
Protocol	In Vivo	Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6493 mL	13.2464 mL	26.4929 mL	52.9857 mL
5mM	0.5299 mL	2.6493 mL	5.2986 mL	10.5971 mL
10mM	0.2649 mL	1.3246 mL	2.6493 mL	5.2986 mL
20mM	0.1325 mL	0.6623 mL	1.3246 mL	2.6493 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.