PF-4840154
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1550 | Check With Us |
| 100mg | $2350 | Check With Us |
| 200mg | $3525 | Check With Us |
: Cat #: V4431 CAS #: 1332708-14-1 Purity ≥ 98%
Description: PF-4840154 is a novel, potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 466.62 |
|---|---|
| Molecular Formula | C26H38N6O2 |
| CAS No. | 1332708-14-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vivo | PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse |
|---|---|---|
| Animal model | Female CD1 mice (25-30g) (In TrpA1+/+ mice) | |
| Dosages | 30 nmol | |
| Administration | Intraplantar (i.pl) injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1431 mL | 10.7154 mL | 21.4307 mL | 42.8614 mL |
| 5mM | 0.4286 mL | 2.1431 mL | 4.2861 mL | 8.5723 mL |
| 10mM | 0.2143 mL | 1.0715 mL | 2.1431 mL | 4.2861 mL |
| 20mM | 0.1072 mL | 0.5358 mL | 1.0715 mL | 2.1431 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.