PF-06928215
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1000 | To Be Confirmed |
| 250mg | $1750 | To Be Confirmed |
| 500mg | $2625 | To Be Confirmed |
: Cat #: V4559 CAS #: 2378173-15-8 Purity ≥ 98%
Description: PF-06928215 (PF06928215) is a novel, potent, high affinity and selective cGAS (cyclic GMP-AMP Synthase) inhibitor with the potential to be used for autoimmune diseases and inflammatory conditions.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 380.40 |
|---|---|
| Molecular Formula | C20H20N4O4 |
| CAS No. | 2378173-15-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | OC([C@@H]1CCCC[C@@H]1NC(C2=C3N(C(O)=CC(C4=CC=CC=C4)=N3)N=C2)=O)=O |
| Synonyms | PF-06928215; PF 06928215; PF06928215 |
| Protocol | In Vitro | PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6288 mL | 13.1441 mL | 26.2881 mL | 52.5762 mL |
| 5mM | 0.5258 mL | 2.6288 mL | 5.2576 mL | 10.5152 mL |
| 10mM | 0.2629 mL | 1.3144 mL | 2.6288 mL | 5.2576 mL |
| 20mM | 0.1314 mL | 0.6572 mL | 1.3144 mL | 2.6288 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.