PF-06928215 (PF06928215) is a novel, potent, high affinity and selective cGAS (cyclic GMP-AMP Synthase) inhibitor with the potential to be used for autoimmune diseases and inflammatory conditions.

G150 (G-150) is a novel, potent and selective inhibitor of h-cGAS (human cyclic GMP-AMP synthase) which inhibits dsDNA-triggered interferon expression with an IC50 of 10.2 nM.

RU.521 (RU320521) is a novel and selective cyclic GMP-AMP synthase (cGAS) inhibitor with potential usefulness for autoimmune diseases.