PF-06282999
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1800 | Check With Us |
| 1g | $2700 | Check With Us |
| 5g | $6835 | Check With Us |
: Cat #: V4475 CAS #: 1435467-37-0 Purity ≥ 98%
Description: PF-06282999 is a novel, potent and selective myeloperoxidase (MPO) inhibitor with the potential for the treatment of cardiovascular diseases.
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| Molecular Weight (MW) | 325.77 |
|---|---|
| Molecular Formula | C₁₃H₁₂ClN₃O₃S |
| CAS No. | 1435467-37-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O |
| Synonyms | PF-06282999; PF06282999; PF06282999 |
| Protocol | In Vitro | PF-06282999 (Compound 8) is a potent and selective myeloperoxidase inhibitor. The estimated EC50 for total PF-06282999 concentration in plasma is 3.8 μM, which corresponds well with the IC50 value obtained in the human whole blood assay of 1.9 μM. |
|---|---|---|
| In Vivo | PF-06282999 is moderately bound to plasma proteins across preclinical species and humans. The blood/plasma ratios for PF-06282999 are 1.1, 1.1, 0.91, 1.2, and 0.94 in mice, rats, dogs, monkeys, and humans, respectively, suggesting that PF-06282999 is equally distributed into plasma and red blood cells. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0697 mL | 15.3483 mL | 30.6965 mL | 61.3930 mL |
| 5mM | 0.6139 mL | 3.0697 mL | 6.1393 mL | 12.2786 mL |
| 10mM | 0.3070 mL | 1.5348 mL | 3.0697 mL | 6.1393 mL |
| 20mM | 0.1535 mL | 0.7674 mL | 1.5348 mL | 3.0697 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.