PF-06256142
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1650 | Check With Us |
| 100mg | $2450 | Check With Us |
| 200mg | $3675 | Check With Us |
: Cat #: V4441 CAS #: 1609583-14-3 (rotation +) Purity ≥ 98%
Description: PF-06256142 is a novel, potent and selective orthosteric agonist of the D1 receptor with D1 EC50 of 30 nM and D1 binding Ki of 12 nM.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 388.44 |
|---|---|
| Molecular Formula | C21H16N4O2S |
| CAS No. | 1609583-14-3 (rotation +) |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | PF-06256142 exhibits IC50 values of <5 μM as an antagonist at the following 4 targets: M1 (4.9 μM); CB1 (2.1 μM); H1 (4.6 μM); Nav 1.5 (1.1 μM) |
|---|---|---|
| In Vivo | PF-06256142 exhibits high oral bioavailability (rat 85%) following oral administration (rat 5 mg/kg). PF-06256142 exhibits terminal elimination half-life (rat 2.3 h) following intravenous administration (rat 5.0 mg/kg). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5744 mL | 12.8720 mL | 25.7440 mL | 51.4880 mL |
| 5mM | 0.5149 mL | 2.5744 mL | 5.1488 mL | 10.2976 mL |
| 10mM | 0.2574 mL | 1.2872 mL | 2.5744 mL | 5.1488 mL |
| 20mM | 0.1287 mL | 0.6436 mL | 1.2872 mL | 2.5744 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.