OTS964 HCl | CAS 1338545-07-5

OTS964 HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1240	Check With Us
500mg	$1750	Check With Us
1g	$2625	Check With Us

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Cat #: V3181 CAS #: 1338545-07-5 Purity ≥ 98%

Description: OTS964 HCl, the hydrochloride salt of OTS-964 and a dimethylated derivative of OTS 514, is a potent and selective inhibitor of TOPK (T-lymphokine-activated killer cell-originated protein kinase) with antitumor effects. It inhibits TOPK with high selectivity and affinity (IC50 = 28 nM).

References: Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition ofcytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	428.98
Molecular Formula	C23H24N2O2S.HCl
CAS No.	1338545-07-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >100 mg/mLr
	Water:<1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC=C4. [H]Cl
Synonyms	OTS964 HCl; OTS-964 HCl; OTS 964 HCl

Protocol	In Vitro	OTS964 hydrochloride (10 nM; 48 hours) suppresses cancer cell proliferation. OTS964 hydrochloride (10 nM; 48 hours) increases cancer cell death
	In Vivo	OTS964 hydrochloride (intravenously; 40 mg/kg on days 1, 4, 8, 11, 15, and 18) makes tumors shrinking even after the treatment and finally revealing complete regression
	Animal model	Nude mice bearing LU-99 lung cancer cells
	Dosages	40 mg/kg
	Administration	Intravenously; on days 1, 4, 8, 11, 15, and 18

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3311 mL	11.6556 mL	23.3111 mL	46.6222 mL
5mM	0.4662 mL	2.3311 mL	4.6622 mL	9.3244 mL
10mM	0.2331 mL	1.1656 mL	2.3311 mL	4.6622 mL
20mM	0.1166 mL	0.5828 mL	1.1656 mL	2.3311 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.