OTS514 HCl (OTS 514; OTS-514), the hydrochloride salt of OTS514, is a novel and highly potent inhibitor of the TOPK (T-LAK cell-originated protein kinase) with potential antineoplastic activity.

OTS514 (OTS-514) is a novel TOPK (T-LAK cell-originated protein kinase) inhibitor with potential anticancer activity.

OTS964 HCl, the hydrochloride salt of OTS-964 and a dimethylated derivative of OTS 514, is a potent and selective inhibitor of TOPK (T-lymphokine-activated killer cell-originated protein kinase) with antitumor effects. It inhibits TOPK with high selectivity and affinity (IC50 = 28 nM).

HI-TOPK-032 is a novel, potent and selective TOPK kinase inhibitor which strongly suppressed TOPK kinase activity in vitro but had little effect on extracellular signal–regulated kinase 1 (ERK1), c-jun—NH2—kinase 1, or p38 kinase activities.

OTS964, a dimethylated derivative of OTS514, is a novel and selective TOPK ((T-lymphokine-activated killer cell-originated protein kinase) inhibitor with potential anticancer activity.