OTS514 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1340 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V2714 CAS #: 2319647-76-0 Purity ≥ 98%
Description: OTS514 HCl (OTS 514; OTS-514), the hydrochloride salt of OTS514, is a novel and highly potent inhibitor of the TOPK (T-LAK cell-originated protein kinase) with potential antineoplastic activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 400.92 |
|---|---|
| Molecular Formula | C21H20N2O2S.HCl |
| CAS No. | 2319647-76-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 80 mg/mL (199.54 mM)r |
| Water: 80 mg/mL (199.54 mM)r | |
| Ethanol: 5 mg/mL (12.47 mM) | |
| SMILES Code | O=C1NC2=C(C(C3=CC=C([C@@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4.[H]Cl |
| Synonyms | OTS-514; OTS 514; OTS514; OTS-514 HCl, OTS 514 Hydrochloride. |
| Protocol | In Vivo | OTS514 (1-5 mg/kg; once a day for 2 weeks; intravenous administration) induces tumor regression in a xenograft model of A549 cells (TOPK-positive lung cancer cells) |
|---|---|---|
| Animal model | Female BALB/cSLC-nu/nu mice bearing a xenograft model of A549 cells | |
| Dosages | 1, 2.5, and 5 mg/kg | |
| Administration | Intravenously treated; once every day for 2 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4943 mL | 12.4713 mL | 24.9426 mL | 49.8853 mL |
| 5mM | 0.4989 mL | 2.4943 mL | 4.9885 mL | 9.9771 mL |
| 10mM | 0.2494 mL | 1.2471 mL | 2.4943 mL | 4.9885 mL |
| 20mM | 0.1247 mL | 0.6236 mL | 1.2471 mL | 2.4943 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.