Ononetin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | In Stock |
| 1g | $750 | In Stock |
| 5g | $2025 | In Stock |
: Cat #: V26922 CAS #: 487-49-0 Purity ≥ 98%
Description: Ononetin, a naturally occurring deoxybenzoin isolated from the Russian traditional medicine plant Ononis spinosa, is a novel and potent TRPM3 (transient receptor potential melastatin 3) channel blocker (IC50=300 nM).
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| Molecular Weight (MW) | 258.27 |
|---|---|
| Molecular Formula | C15H14O4 |
| CAS No. | 487-49-0 |
| Synonyms | Ononetin |
| Protocol | In Vivo | Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8719 mL | 19.3596 mL | 38.7192 mL | 77.4383 mL |
| 5mM | 0.7744 mL | 3.8719 mL | 7.7438 mL | 15.4877 mL |
| 10mM | 0.3872 mL | 1.9360 mL | 3.8719 mL | 7.7438 mL |
| 20mM | 0.1936 mL | 0.9680 mL | 1.9360 mL | 3.8719 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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V1
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Concentration(final)
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.