ONC206
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1250 | Check With Us |
| 1g | $1950 | Check With Us |
| 5g | $5850 | Check With Us |
: Cat #: V14823 CAS #: 1638178-87-6 Purity ≥ 99%
Description: ONC206 (ONC-206; ONC 206), an analogue of ONC201 (TRAIL inducer) and benzyl-flurobenzyl imipridone, is a novel, potent and selective antagonist of the D2-like dopamine receptors (DRD2/3/4) with a broad-spectrum of anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 408.44 |
|---|---|
| Molecular Formula | C23H22F2N4O |
| CAS No. | 1638178-87-6 |
| Protocol | In Vitro | ONC206 selectively antagonizes the D2-like (DRD2/3/4), but not the D1-like (DRD 1/5), subfamily of dopamine receptors |
|---|---|---|
| In Vivo | ONC206 (100 mg/kg;p.o.; every 10 days) causes significant tumor growth inhibition |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4483 mL | 12.2417 mL | 24.4834 mL | 48.9668 mL |
| 5mM | 0.4897 mL | 2.4483 mL | 4.8967 mL | 9.7934 mL |
| 10mM | 0.2448 mL | 1.2242 mL | 2.4483 mL | 4.8967 mL |
| 20mM | 0.1224 mL | 0.6121 mL | 1.2242 mL | 2.4483 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.