Olesoxime (TRO-19622)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $990 | To Be Confirmed |
| 500mg | $1550 | To Be Confirmed |
| 1g | $2325 | To Be Confirmed |
: Cat #: V5150 CAS #: 22033-87-0 Purity ≥ 98%
Description: Olesoxime (formerly known as TRO 19622; RG-6083) is a mitochondrial-targeted neuroprotective agent with EC50 value for increasing cell survival is 3.2±0.2 µM.
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| Molecular Weight (MW) | 399.65 |
|---|---|
| Molecular Formula | C27H45NO |
| CAS No. | 22033-87-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O/N=C1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]4([H])[C@]3([H])CCC2=C\1 |
| Synonyms | NSC 21311; NSC-21311; NSC21311; Olesoxime; TRO-19622; TRO19622; TRO19622; RG6083; RG 6083; RG-6083; |
| Protocol | In Vitro | Exposure to Olesoxime (TRO 19622) (ranging from 0.1 to 10 µM) at 1 h after plating significantly protects primary embryonic rat spinal MNs (that had been cultured for 3 days without brain-derived, ciliary and glia-derived neurotrophic factors) from cell death. At a concentration of 10 µM, Olesoxime (TRO 19622) maintains survival of 74±10% of the neurons supported by a combination of neurotrophic factors (brain-derived, ciliary and glia-derived neurotrophic factors). The mean EC50 in this assay is 3.2±0.2 µM. In addition to preserving MN cell bodies, Olesoxime (TRO 19622) also promotes the outgrowth of neurites. At a concentration of 1 µM, which increases cell survival by only 38%, Olesoxime (TRO 19622) increases overall neurite outgrowth per cell by 54%. |
|---|---|---|
| In Vivo | Daily administration of Olesoxime (TRO 19622) (3 or 30 mg/kg sc) to adult mice for more than 2 months is well tolerated without toxicity or adverse effects. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5022 mL | 12.5109 mL | 25.0219 mL | 50.0438 mL |
| 5mM | 0.5004 mL | 2.5022 mL | 5.0044 mL | 10.0088 mL |
| 10mM | 0.2502 mL | 1.2511 mL | 2.5022 mL | 5.0044 mL |
| 20mM | 0.1251 mL | 0.6255 mL | 1.2511 mL | 2.5022 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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