Emapunil (formerly known as AC-5216 or XBD-173) is an antianxiolytic drug that also has neuroprotective activities.

Olesoxime (formerly known as TRO 19622; RG-6083) is a mitochondrial-targeted neuroprotective agent with EC50 value for increasing cell survival is 3.2±0.2 µM.

CTPI-2 is a novel, potent, specific, and third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM.

BI-6C9 is a novel and potent inhibitor of BH3 interacting domain (Bid) with Kd of 20 µM, it acts by preventing mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protecting the cells from cell death.

KL1333, a novel NAD+ modulator, is a potent, orally bioavailable and small organic molecule with the potential to treat Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).

ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening.

Vatiquinone (formerly also known as EPI-743) is a novel, potent and orally bioavailable cellular oxidative stress protectant and a para-benzoquinone analog being developed for treating inherited mitochondrial diseases.

MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator).

GW-604714X is a novel and potent inhibitor of mitochondrial respiration.

IACS-10759 (IACS10759) is a potent and orally bioavailable inhibitor of OXPHOS (complex I of oxidative phosphorylation) with antitumor effects.