NVR 3-778
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1500 | Check With Us |
| 200mg | $2250 | Check With Us |
| 500mg | $3800 | Check With Us |
: Cat #: V25189 CAS #: 1445790-55-5 Purity ≥ 99%
Description: NVR 3-778 is a first-in-class, potent and oral bioavailable capsid assembly modulator against the hepatitis B virus [HBV CAM].
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| Molecular Weight (MW) | 432.39 |
|---|---|
| Molecular Formula | C18H16F4N2O4S |
| CAS No. | 1445790-55-5 |
| SMILES Code | O=C(NC1=CC(F)=C(F)C(F)=C1)C2=CC=C(F)C(S(=O)(N3CCC(O)CC3)=O)=C2 |
| Synonyms | NVR 3778; NVR-3778; K-89; K 89; K89; NVR3778; NVR 3 778; NVR3 778; NVR-3-778; |
| Protocol | In Vitro | NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral with an EC50 of 0.40 µM in HepG2.2.15 cells. NVR 3-778 exhibits pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81 µM against HBV DNA and between 3.7µM and 4.8 µM against the production of HBV antigens and intracellular HBV RNA. NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles. NVR 3-778 targets HBV core protein and inhibits viral replication. The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively. |
|---|---|---|
| In Vivo | NVR 3-778 (1.5 mg/kg; i.g.) displays the mean Cmax and AUC0–inf values of 0.56 µg/ml and 3.50 µg·h/ml, respectively, in dogs following oral administration. And the mean oral bioavailability is determined to be 84.6%. | |
| Animal model | Dogs |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3127 mL | 11.5636 mL | 23.1273 mL | 46.2545 mL |
| 5mM | 0.4625 mL | 2.3127 mL | 4.6255 mL | 9.2509 mL |
| 10mM | 0.2313 mL | 1.1564 mL | 2.3127 mL | 4.6255 mL |
| 20mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.3127 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.