NSC348884
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $850 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V5039 CAS #: 81624-55-7 Purity ≥ 98%
Description: NSC348884 is a novel and potent nucleophosmin inhibitor that is able to disrupt oligomer formation and induces apoptosis, it inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 636.79 |
|---|---|
| Molecular Formula | C38H40N10 |
| CAS No. | 81624-55-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | CC1=CC=C2N=C(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)NC2=C1 |
| Synonyms | NSC348884; NSC 348884; NSC-348884 |
| Protocol | In Vitro | NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53. NSC348884 (1-5 μM; 24 h) induces cell apoptosis. NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin. NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells. NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation. |
|---|---|---|
| In Vivo | NSC348884 (50 μg; i.p. once) reduces tumor growth. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5704 mL | 7.8519 mL | 15.7038 mL | 31.4075 mL |
| 5mM | 0.3141 mL | 1.5704 mL | 3.1408 mL | 6.2815 mL |
| 10mM | 0.1570 mL | 0.7852 mL | 1.5704 mL | 3.1408 mL |
| 20mM | 0.0785 mL | 0.3926 mL | 0.7852 mL | 1.5704 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.