NSC-87877
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $810 | Check With Us |
| 500mg | $1110 | Check With Us |
| 1g | $1665 | Check With Us |
: Cat #: V3210 CAS #: 56990-57-9 Purity ≥ 98%
Description: NSC-87877 (NSC87877) is a novel, potent, cell-permeable small molecule and competitive inhibitor of SHP-1 and SHP-2 PTP (protein tyrosine phosphatase) with anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 459.45 |
|---|---|
| Molecular Formula | C19H13N3O7S2 |
| CAS No. | 56990-57-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 10mMr |
| Water: ~20 mg/mLr | |
| Ethanol: NA | |
| SMILES Code | OS(C(C=C1)=CC(C1=C2)=CC=C2/N=N/C3=C(O)C4=NC=CC=C4C(S(O)(=O)=O)=C3)(=O)=O |
| Synonyms | NSC 87877; NSC87877; NSC-87877 |
| Protocol | In Vitro | NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines. |
|---|---|---|
| In Vivo | NSC-87877 (30 mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1765 mL | 10.8826 mL | 21.7652 mL | 43.5303 mL |
| 5mM | 0.4353 mL | 2.1765 mL | 4.3530 mL | 8.7061 mL |
| 10mM | 0.2177 mL | 1.0883 mL | 2.1765 mL | 4.3530 mL |
| 20mM | 0.1088 mL | 0.5441 mL | 1.0883 mL | 2.1765 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.