NSC 185058
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3870 | Check With Us |
| 200mg | $5805 | Check With Us |
| 500mg | $9795 | Check With Us |
: Cat #: V5015 CAS #: 39122-38-8 Purity ≥ 98%
Description: NSC 185058 (NSC-185058) is an inhibitor of ATG4B which is a major cysteine protease, and inhibition of ATG4B by NSC185058 markedly attenuates autophagic activity.
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| Molecular Weight (MW) | 215.27 |
|---|---|
| Molecular Formula | C11H9N3S |
| CAS No. | 39122-38-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | S=C(C1=NC=CC=C1)NC2=NC=CC=C2 |
| Synonyms | NSC185058; NSC-185058; NSC 185058; |
| Protocol | In Vitro | NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.6453 mL | 23.2266 mL | 46.4533 mL | 92.9066 mL |
| 5mM | 0.9291 mL | 4.6453 mL | 9.2907 mL | 18.5813 mL |
| 10mM | 0.4645 mL | 2.3227 mL | 4.6453 mL | 9.2907 mL |
| 20mM | 0.2323 mL | 1.1613 mL | 2.3227 mL | 4.6453 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.