NS-11021

This product is for research use only, not for human use. We do not sell to patients.

NS-11021
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Size Price Stock
100mg$720Check With Us
250mg$1250Check With Us
500mg$1875Check With Us

Cat #: V11738 CAS #: 956014-19-0 Purity ≥ 98%

Description: NS-11021 is a novel, potent and selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1).

References: Bo Hjorth Bentzen, et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44

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Product Promise

Promise
Molecular Weight (MW)511.2444
Molecular FormulaC16H9BrF6N6S
CAS No.956014-19-0
SynonymsNS-11021; NS 11021; NS11021.
ProtocolIn VitroNS 11021 (1-30 μM) increases the current of hKCa1.1 from 2 μA to 4 μA at the concentration of 3 μM and can activate the hKCa1.1 expression channel in a dose-dependent manner in X. laevis oocytes
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.9560 mL9.7801 mL19.5601 mL39.1202 mL
5mM0.3912 mL1.9560 mL3.9120 mL7.8240 mL
10mM0.1956 mL0.9780 mL1.9560 mL3.9120 mL
20mM0.0978 mL0.4890 mL0.9780 mL1.9560 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.