Home > Signaling Pathways>Apoptosis>Thymidylate Synthase>Nolatrexed 2HCl
Nolatrexed 2HCl

This product is for research use only, not for human use. We do not sell to patients.

Nolatrexed 2HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$650To Be Confirmed
250mg$1250To Be Confirmed
500mg$1875To Be Confirmed
email: [email protected]        [email protected]

Cat #: V16389 CAS #: 152946-68-4 Purity ≥ 99%

Description: Nolatrexed dHCl (AG-337 dihydrochloride; thymitaq), a folate analog, is a novel and potent thymidylate synthase inhibitor with potential anticancer activity.

References: Webber S, et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)C14H14Cl2N4OS
Molecular Formula357.26
CAS No.152946-68-4
SynonymsNolatrexed 2HCl
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.