Nolatrexed dHCl (AG-337 dihydrochloride; thymitaq), a folate analog, is a novel and potent thymidylate synthase inhibitor with potential anticancer activity.

Tipiracil HCl (formerly known as TPI; TAS-1-462, MA-1; trade name Lonsurf), the hydrochloride salt of tipiracil, is a thymidine phosphorylase inhibitor (TPI) approved for use in combination (TAS-102) with trifluridine for cancer treatment.

Tipiracil (TPI), one of the key components in TAS-102 (trade name Lonsurf, a mixture of Trifluridine and tipiracil hydrochloride in a 1:0.5 molar ratio), is a potent thymidine phosphorylase (TPase) inhibitor with anticancer activity.

Leucovorin (Folinic acid), the active metabolite of folic acid, is used primarily as the calcium salt form as an antidote/rescue agent to folic acid antagonists which block the conversion of folic acid to folinic acid.