Nigericin sodium
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $980 | To Be Confirmed |
| 500mg | $1420 | To Be Confirmed |
| 1g | $2130 | To Be Confirmed |
: Cat #: V4873 CAS #: 28643-80-3 Purity ≥ 98%
Description: Nigericin sodium, the sodium salt of nigericin which is an antibiotic isolated from Streptomyces hygroscopicus, is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 746.94 |
|---|---|
| Molecular Formula | C40H67NaO11 |
| CAS No. | 28643-80-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | Nigericin is more toxic to S18 cells than S26 cells, IC50 They were 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPCs in vitro. Nigericin significantly reduces the migration capacity of S18 and HONE-1 cells |
|---|---|---|
| In Vivo | Ngericin (4 mg/kg, ip) significantly reduced tumor growth and worked synergistically with the chemotherapy agent DDP, as indicated by tumor volume. Nigericin significantly reduces BMI-1 in the body. Overexpression of Bmi-1 partially restored the CSC content and metastasis capacity of NPC cells under Nigerian mycin treatment. The downregulation of BMI-1 may be related to the inhibitory effect of nigmycin on nasopharyngeal carcinoma stem cells |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3388 mL | 6.6940 mL | 13.3880 mL | 26.7759 mL |
| 5mM | 0.2678 mL | 1.3388 mL | 2.6776 mL | 5.3552 mL |
| 10mM | 0.1339 mL | 0.6694 mL | 1.3388 mL | 2.6776 mL |
| 20mM | 0.0669 mL | 0.3347 mL | 0.6694 mL | 1.3388 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.