NICLOSAMIDE (BAY2353)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 25g | $180 | Check With Us |
| 50g | $320 | Check With Us |
| 100g | $480 | Check With Us |
: Cat #: V1381 CAS #: 50-65-7 Purity ≥ 98%
Description: Niclosamide (Clonitralide, Fenasal, BAY-2353, NSC-178296, WR-46234) is a potent and orally bioavailable chlorinated salicylanilide analog with anthelmintic and potential antineoplastic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 327.12 |
|---|---|
| Molecular Formula | C13H8Cl2N2O4 |
| CAS No. | 50-65-7 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 12 mg/mL (36.7 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL |
| SMILES Code | O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O |
| Synonyms | Niclocide; Niclosamide, Clonitralide, Fenasal, BAY 2353, NSC 178296, WR 46234, BAY-2353, NSC-178296, WR-46234, BAY2353, NSC178296, WR46234 |
| Protocol | In Vitro | Niclosamide (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells. |
|---|---|---|
| In Vivo | Niclosamide (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0570 mL | 15.2849 mL | 30.5698 mL | 61.1396 mL |
| 5mM | 0.6114 mL | 3.0570 mL | 6.1140 mL | 12.2279 mL |
| 10mM | 0.3057 mL | 1.5285 mL | 3.0570 mL | 6.1140 mL |
| 20mM | 0.1528 mL | 0.7642 mL | 1.5285 mL | 3.0570 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.