NGB2904 HCl

This product is for research use only, not for human use. We do not sell to patients.

NGB2904 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$450To Be Confirmed
100mg$750To Be Confirmed
200mg$1125To Be Confirmed

Cat #: V26431 CAS #: 189060-98-8 Purity ≥ 99%

Description: NGB2904 HCl (NGB-2904) is a novel, selective, orally bioactive antagonist of dopamine D3 receptor with the potential to be used for cocaine addiction.

References: Yuan J, et, al. NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. Bioorg Med Chem Lett. 1998 Oct 6; 8(19):2715-8.

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Molecular Weight (MW)494.46
Molecular FormulaC28H29Cl2N3O
CAS No.189060-98-8
ProtocolIn VitroNGB 2904 Mitogenesis that antagonizes Quinpirole (100 nM) stimuli, IC50 is 5.0 nM
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.0224 mL10.1120 mL20.2241 mL40.4482 mL
5mM0.4045 mL2.0224 mL4.0448 mL8.0896 mL
10mM0.2022 mL1.0112 mL2.0224 mL4.0448 mL
20mM0.1011 mL0.5056 mL1.0112 mL2.0224 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.