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Nepicastat (SYN-117) HCl

This product is for research use only, not for human use. We do not sell to patients.

Nepicastat (SYN-117) HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$850Check With Us
500mg$1350Check With Us
1g$2025Check With Us
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Cat #: V0932 CAS #: 170151-24-3 Purity ≥ 98%

Description: Nepicastat HCl (SYN-117; SYN 117; RS-25560-197; RS 25560-197), the hydrochloride salt of Nepicastat, is a potent and selective inhibitor of dopamine-β-hydroxylase (an enzyme that catalyzes the conversion of dopamine to norepinephrine) with the potential to treat CHF-congestive heart failure.

References: Beliaev A, et al. Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.J Med Chem. 2006 Feb 9;49(3):1191-7.

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Molecular Weight (MW)331.81
Molecular FormulaC14H15F2N3S.HCl
CAS No.170151-24-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 66 mg/mL (198.9 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeS=C1NC=C(CN)N1[C@@H]2CC3=C(C(F)=CC(F)=C3)CC2.[H]Cl
SynonymsSYN117; RS25560197; RS25560-197; SYN-117; SYN 117; RS-25560-197; RS 25560-197; Nepicastat; Nepicastat HCl
ProtocolIn VivoNepicastat hydrochloride (SYN-117 hydrochloride) (3-100 mg/kg; p.o.; three consecutive times, 12 hours apart times) produces dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery (mesenteric or renal), left ventricle.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0138 mL15.0689 mL30.1377 mL60.2755 mL
5mM0.6028 mL3.0138 mL6.0275 mL12.0551 mL
10mM0.3014 mL1.5069 mL3.0138 mL6.0275 mL
20mM0.1507 mL0.7534 mL1.5069 mL3.0138 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.