Necrostatin-2 racemate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1550 | Check With Us |
| 200mg | $2325 | Check With Us |
| 500mg | $3920 | Check With Us |
: Cat #: V26347 CAS #: 852391-15-2 Purity ≥ 99%
Description: Necrostatin-2, formerly known as (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s, is a racemic mixture of Necrostatin-2 that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation.
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| Molecular Weight (MW) | 277.71 |
|---|---|
| Molecular Formula | C13H12ClN3O2 |
| CAS No. | 852391-15-2 |
| SMILES Code | O=C1N(C)C(C(CC2=CNC3=C2C=CC=C3Cl)N1)=O |
| Synonyms | Necrostatin-2; (±)-Necrostatin-2; 7-Cl-O-Nec-1; Nec-1s; |
| Protocol | In Vitro | Necrostatin 2 racemate (Nec-1S) (1-100 μM; 1 h) potently inhibits RIPK1 autophosphorylation in a dose-dependent manner. |
|---|---|---|
| In Vivo | Necrostatin 2 racemate (Nec-1S) (6 mg/kg; i.v.; once) protects against TNF-induced systemic inflammatory response syndrome (SIRS) without sensitization effect. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6009 mL | 18.0044 mL | 36.0088 mL | 72.0176 mL |
| 5mM | 0.7202 mL | 3.6009 mL | 7.2018 mL | 14.4035 mL |
| 10mM | 0.3601 mL | 1.8004 mL | 3.6009 mL | 7.2018 mL |
| 20mM | 0.1800 mL | 0.9002 mL | 1.8004 mL | 3.6009 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.