NDI-091143
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1300 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V2147 CAS #: 2375840-87-0 Purity ≥ 98%
Description: NDI-091143 (NDI091143) is a novel and potent inhibitor of human ATP-citrate lyase (ACLY) with anticancer activity.
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| Molecular Weight (MW) | 453.84 |
|---|---|
| Molecular Formula | C20H14ClF2NO5S |
| CAS No. | 2375840-87-0 |
| SMILES Code | O=C(OC)C1=CC(S(=O)(NC2=CC(C3=CC=CC=C3)=C(F)C=C2F)=O)=C(O)C(Cl)=C1 |
| Synonyms | NDI091143; NDI 091143; NDI-09114 |
| Protocol | In Vitro | Thermal shift assays shows that NDI-091143 gives rise to considerable stabilization of both full-length ACLY and the N-terminal segment. The thermal shift data are consistent with limited proteolysis experiments using full-length ACLY, in which NDI-091143 together with Mg-ATP provided the greatest protection against digestion by chymotrypsin. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2034 mL | 11.0171 mL | 22.0342 mL | 44.0684 mL |
| 5mM | 0.4407 mL | 2.2034 mL | 4.4068 mL | 8.8137 mL |
| 10mM | 0.2203 mL | 1.1017 mL | 2.2034 mL | 4.4068 mL |
| 20mM | 0.1102 mL | 0.5509 mL | 1.1017 mL | 2.2034 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.