Naproxen [(S)-Naproxen)]
This product is for research use only, not for human use. We do not sell to patients.
![Naproxen [(S)-Naproxen)]](https://invivochem.net/wp-content/uploads/2023/05/6373759433589088461373725128-300x300.png "Naproxen [(S)-Naproxen)]")
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| Size | Price | Stock |
|---|---|---|
| 50g | $350 | Check With Us |
| 100g | $550 | Check With Us |
| 200g | $825 | Check With Us |
: Cat #: V10807 CAS #: 22204-53-1 Purity ≥ 98%
Description: Naproxen (also known as (S)-Naproxen)) is a non-steroidal anti-inflammatory drug (NSAID) which is a nonselective COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
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| Molecular Weight (MW) | 230.26 |
|---|---|
| Molecular Formula | C14H14O3 |
| CAS No. | 22204-53-1 |
| SMILES Code | O=C(O)[C@@H](C)C1=CC=C2C=C(OC)C=CC2=C1 |
| Synonyms | Naproxen; Naposin; Napratec; CG 3117; CG3117; CG-3117; |
| Protocol | In Vitro | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively. |
|---|---|---|
| In Vivo | Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3429 mL | 21.7146 mL | 43.4292 mL | 86.8583 mL |
| 5mM | 0.8686 mL | 4.3429 mL | 8.6858 mL | 17.3717 mL |
| 10mM | 0.4343 mL | 2.1715 mL | 4.3429 mL | 8.6858 mL |
| 20mM | 0.2171 mL | 1.0857 mL | 2.1715 mL | 4.3429 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.