Nabumetone (BRL 14777)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $650 | Check With Us |
| 100g | $980 | Check With Us |
| 200mg | $1470 | Check With Us |
: Cat #: V1072 CAS #: 42924-53-8 Purity ≥ 98%
Description: Nabumetone (formerly BRL-14777; BRL14777; Relafen, Relifex, Gambaran, Arthraxan), a non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor and a prodrug with potential anti-inflammatory activity.
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| Molecular Weight (MW) | 228.29 |
|---|---|
| Molecular Formula | C15H16O2 |
| CAS No. | 42924-53-8 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 46 mg/mL (201.5 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 25 mg/mL (109.5 mM) | |
| SMILES Code | CC(CCC1=CC=C2C=C(OC)C=CC2=C1)=O |
| Synonyms | BRL-14777; Nabumetone, Relafen, BRL14777; BRL 14777; Relifex, Gambaran, Arthraxan |
| Protocol | In Vitro | Nabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3804 mL | 21.9020 mL | 43.8039 mL | 87.6079 mL |
| 5mM | 0.8761 mL | 4.3804 mL | 8.7608 mL | 17.5216 mL |
| 10mM | 0.4380 mL | 2.1902 mL | 4.3804 mL | 8.7608 mL |
| 20mM | 0.2190 mL | 1.0951 mL | 2.1902 mL | 4.3804 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.