This product is for research use only, not for human use. We do not sell to patients.
Size | Price | Stock |
---|---|---|
5mg | $90 | To Be Confirmed |
10mg | $150 | To Be Confirmed |
25mg | $280 | To Be Confirmed |
50mg | $450 | To Be Confirmed |
100mg | $750 | To Be Confirmed |
250mg | $1450 | To Be Confirmed |
Cat #: V3353 CAS #: 783331-24-8 Purity ≥ 98%
Description: MRK-016 (MRK016; MRK 016) is a novel, potent, orally bioactive and selective negative allosteric modulator (inverse agonist) of α5 subunit-containing GABAA with nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression. Also MRK-016 (MRK) can protect against memory acquisition and consolidation errors in mice. Post-training treatment with MRK-016 restored behavioral expression of fear in LPS-treated animals, despite elevated hippocampal Aβ, an effect that may be attributed to increased BDNF mRNA expression. Therefore, these data indicate that MRK-016 can prevent LPS- induced cognitive deficits associated with elevated Aβ, and restore hippocampal BDNF expression.
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- Physicochemical and Storage Information
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- Quality Control Documentation
Molecular Weight (MW) | 368.40 |
---|---|
Molecular Formula | C17H20N8O2 |
CAS No. | 783331-24-8 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: ≥ 10mM |
Water: N/A | |
Ethanol: N/A | |
SMILES Code | CN1N=CN=C1COC2=NN3C(C4=NOC(C)=C4)=NN=CC3=C2C(C)(C)C |
Synonyms | MRK-016; MRK 016; MRK016; MRK |
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.7144 mL | 13.5722 mL | 27.1444 mL | 54.2888 mL |
5mM | 0.5429 mL | 2.7144 mL | 5.4289 mL | 10.8578 mL |
10mM | 0.2714 mL | 1.3572 mL | 2.7144 mL | 5.4289 mL |
20mM | 0.1357 mL | 0.6786 mL | 1.3572 mL | 2.7144 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.