MRK-016

This product is for research use only, not for human use. We do not sell to patients.

MRK-016
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$90To Be Confirmed
10mg$150To Be Confirmed
25mg$280To Be Confirmed
50mg$450To Be Confirmed
100mg$750To Be Confirmed
250mg$1450To Be Confirmed

Cat #: V3353 CAS #: 783331-24-8 Purity ≥ 98%

Description: MRK-016 (MRK016; MRK 016) is a novel, potent, orally bioactive and selective negative allosteric modulator (inverse agonist) of α5 subunit-containing GABAA with nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression. Also MRK-016 (MRK) can protect against memory acquisition and consolidation errors in mice. Post-training treatment with MRK-016 restored behavioral expression of fear in LPS-treated animals, despite elevated hippocampal Aβ, an effect that may be attributed to increased BDNF mRNA expression. Therefore, these data indicate that MRK-016 can prevent LPS- induced cognitive deficits associated with elevated Aβ, and restore hippocampal BDNF expression.

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Product Promise

Promise
Molecular Weight (MW)368.40
Molecular FormulaC17H20N8O2
CAS No.783331-24-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 10mM
Water: N/A
Ethanol: N/A
SMILES CodeCN1N=CN=C1COC2=NN3C(C4=NOC(C)=C4)=NN=CC3=C2C(C)(C)C
SynonymsMRK-016; MRK 016; MRK016; MRK
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7144 mL13.5722 mL27.1444 mL54.2888 mL
5mM0.5429 mL2.7144 mL5.4289 mL10.8578 mL
10mM0.2714 mL1.3572 mL2.7144 mL5.4289 mL
20mM0.1357 mL0.6786 mL1.3572 mL2.7144 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.