MPEP hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $500 | Check With Us |
| 500mg | $850 | Check With Us |
| 1g | $1275 | Check With Us |
: Cat #: V3421 CAS #: 219911-35-0 (HCl); 96206-92-7 (free base) Purity ≥ 98%
Description: MPEP hydrochloride is a highly potent, selective, and non-competitive antagonist of mGlu5 receptor with IC50 of 36 nM, it exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 229.71 |
|---|---|
| Molecular Formula | C14H12ClN |
| CAS No. | 219911-35-0 (HCl); 96206-92-7 (free base) |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >10 mMr |
| Water:r | |
| Ethanol: | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+5% Tween 80: 10 mg/mL |
| Synonyms | 2-methyl-6-(phenylethynyl)-pyridine; MPEP; MPEP HCl; MPEP hydrochloride |
| Protocol | In Vivo | MPEP (1-30 mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice |
|---|---|---|
| Animal model | Male Wistar rats (200 ± 250 g) | |
| Dosages | IP or PO. | |
| Administration | 0.3, 1 and 10 mg/kg, i.p. (Conflict drinking test). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3533 mL | 21.7666 mL | 43.5332 mL | 87.0663 mL |
| 5mM | 0.8707 mL | 4.3533 mL | 8.7066 mL | 17.4133 mL |
| 10mM | 0.4353 mL | 2.1767 mL | 4.3533 mL | 8.7066 mL |
| 20mM | 0.2177 mL | 1.0883 mL | 2.1767 mL | 4.3533 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.