ML355 | CAS 1532593-30-8

ML355

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$980	Check With Us
500mg	$1650	Check With Us
1g	$2475	Check With Us

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Cat #: V3027 CAS #: 1532593-30-8 Purity ≥ 99%

Description: ML355 is the first selective, orally bioavailable 12-LOX inhibitor which displays high potency (IC50 of 0.34 μM) against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases.

References: Luci DK, et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506.

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Physicochemical and Storage Information
Protocol
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Stock Solution Preparation
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Molecular Weight (MW)	441.52
Molecular Formula	C21H19N3O4S2
CAS No.	1532593-30-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >40 mg/mLr
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	15mg/kg in DMSO:Solutol:PEG400:water; 5:10:20:65
SMILES Code	O=S(C1=CC=C(NCC2=CC=CC(OC)=C2O)C=C1)(NC3=NC4=CC=CC=C4S3)=O
Synonyms	ML-355; ML 355; ML355;

Protocol	In Vitro	ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
Protocol	In Vivo	ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2649 mL	11.3245 mL	22.6490 mL	45.2981 mL
5mM	0.4530 mL	2.2649 mL	4.5298 mL	9.0596 mL
10mM	0.2265 mL	1.1325 mL	2.2649 mL	4.5298 mL
20mM	0.1132 mL	0.5662 mL	1.1325 mL	2.2649 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.