ML-SI3
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | In Stock |
| 500mg | $2250 | In Stock |
| 1g | $3375 | In Stock |
: Cat #: V2491 CAS #: 891016-02-7 Purity ≥ 98%
Description: ML SI3 (ML-SI3) is an antagonist of the TRPML family of calcium channels.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 429.58 |
|---|---|
| Molecular Formula | C23H31N3O3S |
| CAS No. | 891016-02-7 |
| Synonyms | ML SI3; ML-SI3; MLSI3; MLSI-3; ML SI 3 |
| Protocol | In Vitro | ML-SI3 (3 µM, 6 h) abolishes the increase in both LC3II and p62 levels induced by hypoxia/reoxygenation (H/R) (4 h H/2 h R) in neonatal rat ventricular myocytes (NRVM) |
|---|---|---|
| In Vivo | ML-SI3 (1.5 mg/kg, i.p., four times) attenuates I/R injury in mouse cardiomyocytes | |
| Animal model | Myocardial Ischemia/reperfusion (I/R) injury mice | |
| Dosages | 1.5 mg/kg | |
| Administration | Intraperitoneal injection (i.p.), four times before and during the in vivo I/R (ischemia 30 min and reperfusion 1 day) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3279 mL | 11.6393 mL | 23.2786 mL | 46.5571 mL |
| 5mM | 0.4656 mL | 2.3279 mL | 4.6557 mL | 9.3114 mL |
| 10mM | 0.2328 mL | 1.1639 mL | 2.3279 mL | 4.6557 mL |
| 20mM | 0.1164 mL | 0.5820 mL | 1.1639 mL | 2.3279 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.