ML-SA1

This product is for research use only, not for human use. We do not sell to patients.

ML-SA1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$550Check With Us
500mg$950Check With Us
1g$1425Check With Us

Cat #: V41526 CAS #: 332382-54-4 Purity ≥ 99%

Description: ML-SA1 is a potent agonist of TRPML1 (transient receptor potential mucolipin 1) with broad spectrum of antiviral activity.

References: Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020; 182:104922.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)362.43
Molecular FormulaC22H22N2O3
CAS No.332382-54-4
ProtocolIn VitroML-SA1 (0~200 μM; A549 cells) indicates that the observed cell lines are not cytotoxic, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly inhibits DENV2,IC at RNA levels50 is 8.93 μM
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7592 mL13.7958 mL27.5915 mL55.1831 mL
5mM0.5518 mL2.7592 mL5.5183 mL11.0366 mL
10mM0.2759 mL1.3796 mL2.7592 mL5.5183 mL
20mM0.1380 mL0.6898 mL1.3796 mL2.7592 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.