MitoEbselen-2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $850 | Check With Us |
| 250mg | $1700 | Check With Us |
| 500mg | $2550 | Check With Us |
: Cat #: V11169 CAS #: 1638973-78-0 Purity ≥ 99%
Description: MitoEbselen-2 (MitoPeroxidase-2), an Ebselen derivative, is a novel and potent radiation mitigator.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 656.01 |
|---|---|
| Molecular Formula | C35H30ClN2O2PSe |
| CAS No. | 1638973-78-0 |
| SMILES Code | O=C(NCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=C(N5[Se]C6=CC=CC=C6C5=O)C=C4.[Cl-] |
| Synonyms | MitoEbselen-2; MitoEbselen 2; MitoPeroxidase 2; MitoPeroxidase-2; |
| Protocol | In Vitro | MitoEbselen-2 chloride (5-20 μM; 30 min) affords ∼50% radioprotection/mitigation of mouse embryonic cells at the concentration of 20 μM. |
|---|---|---|
| In Vivo | MitoEbselen-2 chloride (100 μL of 4 mg/mL; i.v.) increases the survival of mice exposed to whole body γ-irradiation. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5244 mL | 7.6218 mL | 15.2437 mL | 30.4873 mL |
| 5mM | 0.3049 mL | 1.5244 mL | 3.0487 mL | 6.0975 mL |
| 10mM | 0.1524 mL | 0.7622 mL | 1.5244 mL | 3.0487 mL |
| 20mM | 0.0762 mL | 0.3811 mL | 0.7622 mL | 1.5244 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.